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Environmental Protection Agency Office of Research and Development National Health and Environmental Effects Research Laboratory Mid-Continent Ecology Division Duluth, MN 55804 Recycled/Recyclable Printed with Introduction. • ;, ELSEVIER Thermochimica Acta 308 (1998) 3-22 therm0chimica acta Interaction between water and hydrophilic polymersl Hyoe Hatakeyamaa'*, Tatsuko Hatakeyama2'b a Fukui Institute of Technology, 3-6-3, Gakuen, Fukui 910, Japan b National Institute of Materials and Chemical Research, 1-1, Higashi, Tsukuba, lbaraki 305, Japan Received 15 October 1996; received in revised form 9 January Indeed, in a study of breast cancer, using immunohistochemistry with phospho-specific antibodies against Thr 172 on AMPK and Ser 80 on ACC1 (a well-established AMPK target), it was shown that AMPK activation appeared to be down-regulated (in the tumor compared with normal epithelium) in 90% of 350 cases. Most of the chapters in the guideline follow a set layout, as described below. 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